How to Use This Tool
This tool predicts a solute's quantitative solubility across the entire compositional range of a two-solvent (binary) mixture, helping you find **synergistic solubility peaks** where a mixture is a better solvent than either of its pure components.
- Enter Solute Data: Fill in all 7 physical and HSP properties for your solute.
- Select Solvents: Choose the two solvents (A and B) you wish to blend.
- Choose Prediction Mode:
- For a quick **Exploratory Prediction**, enter an estimated `k`-factor (refer to the table below) and click **"Generate Diagram (with Manual `k`)"**.
- For a high-accuracy **Calibrated Prediction**, enter one known experimental solubility data point (for either pure Solvent A or B) and click **"Calibrate `k` & Generate Diagram"**.
- Analyze the Diagram: The chart will show the solubility curve. The summary below will highlight the mixture with the highest predicted solubility.
Guide to the Interaction Correction Factor (k)
The `k`-factor tunes the calculation for specific chemical interactions. Use this table for a good starting estimate:
| System Type (Solute in Solvent) | Indicative `k` Value |
|---|
| Non-polar in Non-polar | 0.8 - 1.0 |
| Polar in Polar (no strong H-Bonds) | 0.3 - 0.6 |
| System with strong Hydrogen Bonding | 0.02 - 0.2 |